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Page 1
Exploration of the damage and mechanisms of BPS exposure on the uterus and ovary of adult female mice.
Yue H, Tian Y, Wu X, Yang X, Xu P, Zhu H, Sang N. Yue H, et al. Sci Total Environ. 2023 Apr 10;868:161660. doi: 10.1016/j.scitotenv.2023.161660. Epub 2023 Jan 20. Sci Total Environ. 2023. PMID: 36690098
Hematoxylin-eosin (H&E) staining results showed significant histological alterations in the uterus and ovary of the BPS-exposed mice. Bioinformatics analysis of the RNA-seq screened a certain number of differentially expressed genes (DEGs) in both uterus and ova …
Hematoxylin-eosin (H&E) staining results showed significant histological alterations in the uterus and ovary of the BPS-exposed m …
Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring.
Xu D, Luo HW, Hu W, Hu SW, Yuan C, Wang GH, Zhang L, Yu H, Magdalou J, Chen LB, Wang H. Xu D, et al. FASEB J. 2018 Oct;32(10):5563-5576. doi: 10.1096/fj.201701557R. Epub 2018 May 2. FASEB J. 2018. PMID: 29718709
We further found that the cholesterol levels were increased in fetal livers but were decreased in fetal blood, accompanied by increased maternal blood cholesterol levels and reduced placental cholesterol transport. Furthermore, analysis of PCE offspring in the uterus and i …
We further found that the cholesterol levels were increased in fetal livers but were decreased in fetal blood, accompanied by increased mate …
Induction of immune-related gene expression by seminal exosomes in the porcine endometrium.
Bai R, Latifi Z, Kusama K, Nakamura K, Shimada M, Imakawa K. Bai R, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1094-1101. doi: 10.1016/j.bbrc.2017.11.100. Epub 2017 Nov 17. Biochem Biophys Res Commun. 2018. PMID: 29155178
Transcripts related to "immune response", "inflammatory response" and their associated signaling pathways were up-regulated in EECs treated with seminal exosome, whereas those associated with "steroid biosynthesis", "metabolic pathways" and "T cell differentiation" were down-regu …
Transcripts related to "immune response", "inflammatory response" and their associated signaling pathways were up-regulated in EECs treated …
HOXA10 Regulates the Synthesis of Cholesterol in Endometrial Stromal Cells.
Yu M, Tang J, Huang Y, Guo C, Du P, Li N, Quan Q. Yu M, et al. Front Endocrinol (Lausanne). 2022 Apr 25;13:852671. doi: 10.3389/fendo.2022.852671. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35546998 Free PMC article.
RESULTS: HOXA10 in ESC was significantly higher expressed than that in OESC. Six key genes (HMGCR, MSMO1, ACAT2, HMGCS1, EBP, and SQLE), which were regulated by HOXA10, were identified from the salmon4 module by WGCNA. ...
RESULTS: HOXA10 in ESC was significantly higher expressed than that in OESC. Six key genes (HMGCR, MSMO1, ACAT2, HMGCS1, EBP, and SQL …
Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells.
Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Villanueva JA, et al. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62. doi: 10.1210/jc.2012-3387. Epub 2013 Feb 5. J Clin Endocrinol Metab. 2013. PMID: 23386644 Free PMC article.
RESULTS: Resveratrol inhibited cholesterol biosynthesis, HMGCR mRNA, and enzyme activity. Simvastatin inhibited cholesterol biosynthesis and enzyme activity but increased HMGCR mRNA and protein expression. Resveratrol potentiated the inhibitory effects of simvastati …
RESULTS: Resveratrol inhibited cholesterol biosynthesis, HMGCR mRNA, and enzyme activity. Simvastatin inhibited cholesterol biosynthe …
Simvastatin decreases invasiveness of human endometrial stromal cells.
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Sokalska A, et al. Biol Reprod. 2012 Jul 5;87(1):2, 1-6. doi: 10.1095/biolreprod.111.098806. Print 2012 Jul. Biol Reprod. 2012. PMID: 22492974 Free PMC article.
Recently we reported that statins, the competitive inhibitors of the key enzyme regulating the mevalonate pathway, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), decrease proliferation of human endometrial stromal (HES) cells. ...The present study was undertaken …
Recently we reported that statins, the competitive inhibitors of the key enzyme regulating the mevalonate pathway, 3-hydroxy-3-methylglutary …
Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency.
Hong L, Xu X, Huang J, Lei M, Xu D, Zhao S, Yu M. Hong L, et al. Sci Rep. 2016 Feb 8;6:20503. doi: 10.1038/srep20503. Sci Rep. 2016. PMID: 26852751 Free PMC article.
Here we reported that during the peri-implantation period in pigs, ABCA1 was expressed by uterine luminal epithelium (LE) and interestingly, its expression was more abundantly in LE on mesometrial side of uterus. However, SR-BI was expressed primarily by LE, glandular epit …
Here we reported that during the peri-implantation period in pigs, ABCA1 was expressed by uterine luminal epithelium (LE) and interestingly, …
A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.
Stormo C, Kringen MK, Grimholt RM, Berg JP, Piehler AP. Stormo C, et al. BMC Mol Biol. 2012 Sep 18;13:29. doi: 10.1186/1471-2199-13-29. BMC Mol Biol. 2012. PMID: 22989091 Free PMC article.
The aim of this study was to identify novel alternatively spliced variants of HMGCR with potential physiological importance. RESULTS: Bioinformatic analyses predicted three novel HMGCR transcripts containing an alternative exon 1 (HMGCR-1b, -1c, -1d) compared …
The aim of this study was to identify novel alternatively spliced variants of HMGCR with potential physiological importance. RESULTS: …
Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability.
Piotrowski PC, Kwintkiewicz J, Rzepczynska IJ, Seval Y, Cakmak H, Arici A, Duleba AJ. Piotrowski PC, et al. Biol Reprod. 2006 Jul;75(1):107-11. doi: 10.1095/biolreprod.106.051763. Epub 2006 Mar 29. Biol Reprod. 2006. PMID: 16571871
Statins, inhibitors of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMGCR), have been shown to decrease proliferation of several mesenchymal tissues. Actions of statins may be related to decreased availability of cholesterol as well as intermediate metabolites of the me …
Statins, inhibitors of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMGCR), have been shown to decrease proliferation of several m …